Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy

Study Purpose

The aim of this study is to assess the safety and efficacy of AloCELYVIR, which consist in bone marrow-derived allogenic mesenchymal stem cells infected with an oncolytic Adenovirus, ICOVIR-5. It has recently been proven that this type of cells are able of transporting oncolytic substances to tumor targets that are difficult to reach, such as medulloblastomas and gliomas, youth cancers located in the cranial cavity that have a poor prognosis and a fatal outcome. In addition, to exerting an anti-tumor action, this virus has the ability to stimulate the immune response, making the therapy even more effective. Thus, the diffuse intrinsic pontine glioma and the medulloblastoma in relapse/progression have been chosen to study the potential of this new advanced therapy through a weekly infusion for 8 weeks.

Recruitment Criteria

Accepts Healthy Volunteers Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms	No
Study Type An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies.	Interventional
Eligible Ages	1 Year - 21 Years
Gender	All

More Inclusion & Exclusion Criteria

INCLUSION CRITERIA COMMON TO THE TWO COHORTS. 1. Patients aged 1 to 21 years. 2. Written informed consent signed by the patients legal representative and, if applicable, the minor (informed consent in patients 12 years of age or older). 3. Measurable or evaluable disease according to RANO criteria. 4. Appropriate functional status, organic function (renal, hepatic) and hematological values:

- Lanksy and karnofsky functional status ≥50%.

Patients who use a wheelchair due of tumor-associated paralysis will be considered as outpatients for functional status evaluation.

- Haematology function: - Platelet count ≥75.000/µL (without support for 3 days) - Absolute neutrophil count (ANC) ≥500/ µL (without growth factor for 3 days) - Hemoglobin ≥ 8 g/dL (Transfusion allowed) - Liver and renal function.

- Glomerular filtration rate (GFR) (estimated by Schwartz ) >60 mL/min/1.73 m2.

- Total bilirubin ≤ 1.5 × the upper limit of normal (ULN) - Transaminases (GOT and GPT) ≤3 × the upper limit of normal (ULN).

≤ 5 times ULN for patients with hepatic metastasis. 5. Patient able to comply with treatment and schedule of visits and assessments. 6. Life expectancy of ≥8 weeks. 7. Appropriate contraceptive methods for sexually active males and females of childbearing age. 8. Negative pregnancy test in blood or urine for females of childbearing age. INCLUSION CRITERIA COMMON TO THE COHORT A. 1. Patient with new DIPG diagnosis (clinical, radiological, or histological in case a biopsy was performed before being included in the study). 2. Not having received previous treatment with radiotherapy or chemotherapy. 3. Patient able to receive radiotherapy. INCLUSION CRITERIA COMMON TO THE COHORT B. 1. Patient diagnosed with relapsed and/or refractory medulloblastoma. Patients must have received at least surgery, radiation therapy and chemotherapy as part of standard treatment and have failed these treatments before they can participate in this study. 2. To be recovered to ≤ G1 from the toxic effects according to CTCAE derived from the previous treatments, excluding ototoxicity, alopecia and peripheral neurotoxicity. EXCLUSION CRITERIA COMMON TO THE TWO COHORTS. 1. Previous treatment with CELYVIR or AloCELYVIR. 2. Known active bacterial, viral, fungal or parasitic infection not controlled. 3. Known active Hepatitis B or C virus or VIH infection. 4. If patients are treated with corticosteroids, they should be clinically stable and on stable or tapering doses of steroids for at least one week. 5. To be receiving another anti-cancer treatment not foreseen in this protocol or to anticipate receiving it during the patient's participation in the same concomitant with the experimental treatment. 6. Clinically significant or uncontrolled serious active and past systemic diseases that may pose an added risk to the patient. EXCLUSION CRITERIA COMMON TO THE COHORT A. 1. Spontaneous massive intratumoral bleeding. Patients with postoperative bleeding (in case of biopsy or surgery) may be included in the study provided that the bleeding is controlled. The same rule applies for other postoperative complications (infection, loss of cerebrospinal fluid, absence of wound closure, subdural collection ...) 2. Patients who have previously received radiotherapy to the brain stem for another malignancy. EXCLUSION CRITERIA COMMON TO THE COHORT B. 1. Washout period respect to previous treatments:

- At least two weeks since the last dose of chemotherapy.

For patients receiving low-dose metronomic oral chemotherapy, this period is at least one week.

- At least four weeks since the autologous hematopoietic stem cell transplant.

- At least two weeks since the last focal radiotherapy or six weeks in case of cranio-spinal radiotherapy.

- At least 2 weeks or 5 half-lifes (whichever occurs first) since the last dose of a biological or investigational treatment.

Trial Details

Trial ID: This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.	NCT04758533
Phase Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.	Phase 1/Phase 2
Lead Sponsor The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.	Hospital Infantil Universitario Niño Jesús, Madrid, Spain
Principal Investigator The person who is responsible for the scientific and technical direction of the entire clinical study.	Álvaro Lassaletta Atienza, MD
Principal Investigator Affiliation	Hospital Infantil Universitario Niño Jesús
Agency Class Category of organization(s) involved as sponsor (and collaborator) supporting the trial.	Other, Industry
Overall Status	Recruiting
Countries	Spain
Conditions The disease, disorder, syndrome, illness, or injury that is being studied.	Diffuse Intrinsic Pontine Glioma, Medulloblastoma, Childhood, Recurrent

Arms & Interventions

Arms

Experimental: AloCELYVIR

Patients will received weekly infusion of AloCELYVIR during 8 weeks.

Interventions

Biological: - AloCELYVIR

Mesenchymal allogenic cells + ICOVIR-5: 500.000 cells/kg

Contact a Trial Team

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