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18F-FET PET in Childhood Brain Tumours
FET PET 2010 is a prospective, multicentre trial aiming to evaluate the additional benefit of FET PET in the assessment of remission after first line therapy and during follow-up
1 Year - 17 YearsLearn More -
Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors
This is a Phase I clinical trial evaluating abemaciclib (LY2835219), an inhibitor of cyclin dependent-kinases 4 and 6 (Cdk 4/6) in children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) (Stratum A) and in relapsed/refractory/progressive malignant brain (Grade III/IV, including DIPG; MBT) and solid tumor (ST) patients (Stratum B).
2 Years - 25 YearsLearn More -
A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
Historically, medulloblastoma treatment has been determined by the amount of leftover disease present after surgery, also known as clinical risk (standard vs. high risk). Recent studies have shown that medulloblastoma is made up of distinct molecular subgroups which respond differently to treatment. This suggests that clinical risk alone is not adequate to identify actual risk of recurrence. In order to address this, we will stratify medulloblastoma treatment in this phase II clinical trial based on both clinical risk (low, standard, intermediate, or high risk) and molecular subtype (WNT, SHH, or Non-WNT Non-SHH). This stratified clinical...
3 Years - 39 YearsLearn More -
Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas
This study is to evaluate the efficacy and safety of ABT-414 alone or with temozolomide versus temozolomide or lomustine alone in participants with recurrent glioblastoma multiforme. The study includes a Pediatric sub-study to evaluate safety, tolerability and pharmacokinetics of ABT-414 in a pediatric population. Adult enrollment has been completed and the study is now only recruiting for pediatric participants.
N/A - 99 YearsLearn More -
A Feasibility Safety Study of Benign Centrally-Located Intracranial Tumors in Pediatric and Young Adult Subjects
The goal of this prospective, non-randomized, single-arm, feasibility study is to develop data to evaluate the safety and feasibility of ExAblate 4000 treatment of benign intracranial tumors which require clinical intervention in pediatric and young adult subjects. Indication of Use: Ablation of benign intracranial tumors in children and young adults which are ExAblate accessible.
8 Years - 22 YearsLearn More -
A Novel Health Information Technology System (BMT Roadmap) for Pediatric BMT Patients and Caregivers
Hematopoietic cell transplantation (BMT), or commonly referred to as blood and marrow transplantation (BMT), is a potentially life-saving therapy for many malignant and non-malignant conditions. Despite advances over the past decade, which have led to improved outcomes, BMT remains an intense treatment modality often requiring prolonged inpatient-based care. While many patients endure the acute complications of the procedure, it is common for BMT patients and their caregivers to experience increased risk of financial and emotional burden, hospital readmission, and health service utilization. This highlights the importance of active...
10 Years - 75 YearsLearn More -
Anti-Angiogenic Therapy Post Transplant (ASCR) for Pediatric Solid Tumors
The purpose of this research study is to determine whether taking either of two low dose drugs that would prevent new blood vessels from growing after stem cell transplant is feasible, and what the side effects of taking each of these drugs after autologous transplant might be. The reason the investigators are looking at these drugs is because one of the things that allows tumors to grow quickly is their ability to stimulate the growth of new blood vessels. By suppressing the growth of new blood vessels after stem cell transplant, the investigators hope to prevent the tumors from coming back or continuing to grow.
6 Months - 21 YearsLearn More -
A Phase II Study of NovoTTF-200A Alone and With Temozolomide in Patients With Low-Grade Gliomas
The purpose of this study is to test the effectiveness and safety of the NovoTTF-200A device in patients with low-grade glioma when it's used by itself or used together with temozolomide. Researchers would also like to know whether the use of NovoTTF-200A, with or without temozolomide, is associated with fewer negative side effects on mental function that may be seen with other currently used treatment options.
18 Years and OverLearn More -
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas
This is a study to determine the safety and efficacy of the drug, mebendazole, when used in combination with standard chemotherapy drugs for the treatment of pediatric brain tumors. Mebendazole is a drug used to treat infections with intestinal parasites and has a long track record of safety in humans. Recently, it was discovered that mebendazole may be effective in treating cancer as well, in particular brain tumors. Studies using both cell cultures and mouse models demonstrated that mebendazole was effective in decreasing the growth of brain tumor cells. This study focuses on the treatment of a category of brain tumors called gliomas....
1 Year - 21 YearsLearn More -
A Pilot Study of Glioma Associated Antigen Vaccines in Conjunction With Poly-ICLC in Pediatric Gliomas
The overall objective of this pilot study is to collect immunological and safety data following administration of vaccinations with HLA-A2. This data will be used to decide whether a larger study of clinical efficacy is warranted.
12 Months - 21 YearsLearn More
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Clinical Trial Finder
Clinical trials are research studies that are critical to finding better and safer treatments. They are at the heart of medical advances and rely on volunteer participation by healthy individuals and people with an illness. People often take part after hearing about clinical trials from their family’s doctor. But you can also actively look online for options.
The Pediatric Brain Tumor Foundation’s Clinical Trial Finder is a tool to help people learn about clinical trials that are enrolling children and/or adolescents diagnosed with a brain tumor. We strongly recommend that you talk to your child’s doctor about the trials that interest you.
Finding a Pediatric Brain Tumor Trial
Start your clinical trial search by filling in your information below, then click on the “Search Trials” button to launch your search. Click on any of the search results to review a particular trial’s details.
If you are interested in learning more about a childhood brain tumor trial, view the ‘Contact a Trial Team’ section for that clinical trial and pick the trial site nearest to you to find their email and phone number. We also strongly recommend that you talk to your child’s doctor about the trials that interest you and read our terms of service below.
The clinical trial information on this website comes from ClinicalTrials.gov, a service of the U.S. National Institutes of Health that provides information on publicly and privately supported clinical studies of human participants with locations in all 50 states and in 196 countries. For general questions about conducting a search, please email us at info@curethekids.org.
Finding Support for Your Child’s Brain Tumor Journey
At the Pediatric Brain Tumor Foundation, we believe that no family should have to face their child’s diagnosis alone. In addition to our clinical trial finder, the PBTF provides support programs to equip, educate and empower families through every stage of their journey. If you would like to learn more, please complete our family profile form or email info@curethekids.org.
The content on this website regarding clinical trials is provided by a third party, Clinical Trial Connect. This content is for informational purposes only and is not to be, and should not be, considered medical advice or a substitute for medical consultation with your or your child’s healthcare provider. The Pediatric Brain Tumor Foundation (“PBTF” or “we”) does not recommend, guarantee, warrant, or endorse any clinical trial listed on this website, and you are advised to discuss the information shown with your child’s healthcare provider. While we believe the information presented on this website to be accurate at the time of writing, we do not guarantee that its contents are correct, complete, or applicable to any particular individual situation. We strongly encourage individuals and families to seek out appropriate medical advice and treatment from a licensed medical professional. We cannot guarantee the availability of any clinical trial listed on this website and will not be responsible if you or a family member are considered ineligible to participate in a given clinical trial. Participation in a clinical trial listed on this website or reliance on any information provided on this website is solely at your own risk, and the PBTF shall not be liable for any injury arising as a result of participation. For a full description of the Terms of Use for the PBTF’s website, please refer to our Terms, Conditions & Privacy page.
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