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Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma
Study Purpose
Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving radiation with concomitant and adjuvant temozolomide versus radiation with adjuvant PCV is more effective in treating anaplastic glioma or low grade glioma.
Recruitment Criteria
|
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Pre-Registration
Inclusion Criteria:
- - United States (US) and Canadian sites: * This review is mandatory prior to registration to confirm eligibility; patients must be willing to submit tissue samples for mandatory central pathology review submission; it should be initiated as soon after surgery as possible.
- - Tissue must have been determined to have local 1p/9q co-deletion and IDH mutation prior to submission for central path review.
- - Tumor tissue must show co-deletion of chromosomes 1p and 19q; for eligibility, the 1p/19q analysis results will be accepted from the local site, as determined by either a locally available or reference laboratory (for US, must be Clinical Laboratory Improvement Act [CLIA] certified); acceptable methods for determination of 1p/19q loss include fluorescent in-situ hybridization (FISH), by genomic sequencing or methylomic analyses; US and Canadian sites must send a copy of the official report to the pathology coordinator and quality assurance specialist (QAS) - Tumor must also show evidence of IDH mutation by immunohistochemistry or genomic analyses; this should be performed at the local site (US: performed in a CLIA certified laboratory); the site must send a copy of the official report to the pathology coordinator and QAS.
Inclusion Criteria:
- - Newly diagnosed and =< 3 months from surgical diagnosis; patients are also eligible if they have had a prior surgical procedure > 3 months earlier for low grade glioma, as long as the patient has not received prior radiation or prior chemotherapy.
- - Histological evidence of World Health Organization (WHO) grade III anaplastic glioma or WHO grade II low grade glioma with locally diagnosed combined 1p/19q loss and the presence of an either IDH1 or IDH2, both as established by a local or referenced laboratory qualified for the study.
- - Patients with codeleted low grade gliomas must also be considered "high risk" by exhibiting one or more of the following characteristics: - Age >= 40 and any surgical therapy.
- - Age < 40 with prior and subtotal resection or biopsy (i.e., anything less than gross total resection) - Documented growth following prior surgery (NOTE: patients with prior surgery cannot have received prior radiation, chemotherapy or targeted therapy) - Intractable seizures.
- - Surgery (partial or gross total resection or biopsy) must be performed >= 2 weeks prior to registration; patient must have recovered adequately from the effects of surgery.
- - Absolute neutrophil count (ANC) >= 1,500/mm^3 obtained =< 21 days prior to registration.
- - Platelet (PLTs) count >= 100,000/mm^3 obtained =< 21 days prior to registration.
- - Hemoglobin (Hgb) > 9.0 g/dL obtained =< 21 days prior to registration.
- - Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) obtained =< 21 days prior to registration.
- - Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) =< 3 x ULN obtained =< 21 days prior to registration.
- - Creatinine =< 1.5 x ULN obtained =< 21 days prior to registration.
- - Negative serum or urine pregnancy test done =< 7 days prior to registration, for women of childbearing potential only.
- - Willingness and ability to personally complete neurocognitive testing (without assistance) and willingness to complete the QOL testing, (either personally or with assistance) - Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0, 1 or 2.
- - Written informed consent.
- - Willingness to return to enrolling institution for follow-up during the active monitoring phase (that is, the active treatment and observation portion) of the study); patients who have been formally transferred to another active and approved site participating in this study would not need to return to the enrolling institution for this purpose.
- - Willingness to allow the provision of tissue samples for correlative research, as long as adequate tissues are available; patients will not be excluded from participation in the study, if they are willing to allow provision of tissues for the correlative research, but there are insufficient quantities of tissue for the correlative analyses (e.g., a patient otherwise eligible and willing who had biopsy only) Willingness to allow the provision of blood samples for correlative research; patients are not excluded from participation in the study, if they are willing to provide the mandatory biospecimens for translational/correlative research, but for logistical reasons the specimens(s) were not obtainable or if the volume collected was insufficient.
Exclusion Criteria:
- - The following categories are ineligible: - Pregnant women.
- - Nursing women.
- - Men or women of childbearing potential who are unwilling to employ adequate contraception or contraceptive method during this study and 6 months following the completion of chemotherapy treatments.
- - History of prior radiation therapy or chemotherapy for glioma; note: patients who have a history of prior low grade glioma (with or without a distant history of prior surgery for that glioma), but who have never received prior chemotherapy or radiation therapy for the glioma are eligible for the study.
- - Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens.
- - Concomitant serious immunocompromised status (other than that related to concomitant steroids) that would compromise the safety of the patient on the study.
- - Patients known to be human immunodeficiency virus (HIV) positive and currently receiving retroviral therapy are not eligible; note: patients known to be HIV positive, but without clinical evidence of an immunocompromised state, are eligible for the study.
- - Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
- - Receiving any other investigational agent that would be considered as a treatment for the primary neoplasm.
- - Other active malignancy within 5 years of registration; exceptions: non-melanotic skin cancer or carcinoma-in-situ of the cervix; note: if there is a history of prior malignancy, the patient is not eligible if they are receiving other specific treatment (with the exclusion of hormonal therapy or Her-2 inhibitors) for their cancer or if they have received prior total body irradiation which included the brain.
- - History of myocardial infarction =< 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias.
Trial Details
|
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT00887146 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Alliance for Clinical Trials in Oncology |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Kurt Jaeckle, MD |
| Principal Investigator Affiliation | Mayo Clinic |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Recruiting |
| Countries | Austria, Belgium, Canada, France, Netherlands, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Brain and Central Nervous System Tumors |
| Study Website: | View Trial Website |
This study will be a randomized phase III for patients with newly diagnosed co-deleted 1p/19q anaplastic glioma or high risk low grade glioma. The trial will only enroll patients with 1p/19q co-deletion. This study includes two arms as described in the "Arms" section. A dynamic allocation procedure will be used to allocate an equal number of patients to different arms (Arms A:B = 1:1). This procedure will balance the marginal distributions of the stratification factors among arms. The stratification factors that will be used are cooperative groups (EORTC vs.#46; all North American groups), age (≤ 50 vs.#46; > 50), performance score (ECOG 0-1 vs.#46; 2), and tumor grade (anaplastic glioma vs.#46; low grade glioma). The primary goal is to determine whether patients who receive radiotherapy with concomitant temozolomide (TMZ) followed by adjuvant temozolomide (RT + TMZ --> TMZ) (Arm B) have a marginally better progression free survival (PFS) as compared with patients who receive radiotherapy followed by PCV chemotherapy (RT --> PCV)(Arm A). Secondary Goals: 1. Time to Progression
- - To determine whether patients who receive (RT + TMZ --> TMZ) have a significantly longer time to progression (clinical or radiographic progression) as compared with patients who receive radiotherapy followed by adjuvant PCV chemotherapy (RT --> PCV).
- - To determine whether there is a difference in survival based on t(1;19)(q10, p10) translocation status and MGMT promoter hypermethylation status.
- - To perform descriptive comparisons of additional secondary outcome endpoints, including overall survival, objective tumor response, prognostic factor analysis and quality of life.
- - To determine the toxicity of the treatment in each arm and perform descriptive comparisons.
- - To determine the neurocognitive and QOL effects in patients treated on this protocol and correlate these results with outcome endpoints.
- - To store blood products (i.e., plasma, DNA and buffy coat), tumor tissue and MRI/CT images for future scientific investigations.
Arms
Experimental: Arm A (RT, procarbazine, lomustine, vincristine)
Patients undergo 3D-CRT or IMRT on days 1-5 for 5-7 weeks. Patients also receive procarbazine hydrochloride PO on days 8-21, lomustine PO on day 1 and vincristine sulfate IV on days 8 and 29 of courses 3-8. Treatment repeats every 6-7 weeks for up to 6 courses in the absence of disease progression or unacceptable toxicity.
Experimental: Arm B (RT, temozolomide)
Patients undergo RT as in arm I and receive temozolomide PO QD on days 1-5 for 5-7 weeks. Beginning 4 weeks after completion of concurrent chemoradiotherapy, patients receive adjuvant temozolomide PO QD days 1-5. Treatment with adjuvant temozolomide repeats every 4 weeks for 6-12 courses in the absence of disease progression and unacceptable toxicity.
Interventions
Drug: - concomitant temozolomide (TMZ)
75 mg/m^2, orally daily
Radiation: - radiotherapy
Drug: - procarbazine
Days 8-21: 60 mg/m^2 orally
Drug: - adjuvant temozolomide (TMZ)
150 or 200 mg/m^2 orally
Drug: - CCNU
Day 1: 110 mg/m^2 orally
Drug: - vincristine
Days 8 and 29: 1.4 mg/m^2 IV
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Recruiting
Address
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233
Status
Suspended
Address
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, 98508
Site Contact
Status
Suspended
Address
Alaska Oncology and Hematology LLC
Anchorage, Alaska, 99508
Site Contact
Status
Suspended
Address
Alaska Women's Cancer Care
Anchorage, Alaska, 99508
Site Contact
Status
Suspended
Address
Anchorage Oncology Centre
Anchorage, Alaska, 99508
Site Contact
Status
Recruiting
Address
Providence Alaska Medical Center
Anchorage, Alaska, 99508
Status
Recruiting
Address
Saint Joseph's Hospital and Medical Center
Phoenix, Arizona, 85013
Status
Suspended
Address
Arizona Oncology-Deer Valley Center
Phoenix, Arizona, 85027
Site Contact
Status
Suspended
Address
Arizona Oncology Services Foundation
Scottsdale, Arizona, 85260
Site Contact
Status
Recruiting
Address
Kaiser Permanente-Anaheim
Anaheim, California, 92806
Status
Suspended
Address
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California, 95603
Site Contact
Status
Suspended
Address
Mills-Peninsula Medical Center
Burlingame, California, 94010
Site Contact
Status
Suspended
Address
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, California, 95682
Site Contact
Status
Active, not recruiting
Address
Community Cancer Institute
Clovis, California, 93611
Site Contact
Status
Active, not recruiting
Address
University Oncology Associates
Clovis, California, 93611
Site Contact
Status
Recruiting
Address
UC San Diego Moores Cancer Center
La Jolla, California, 92093
Status
Recruiting
Address
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, 90027
Status
Active, not recruiting
Address
Cedars Sinai Medical Center
Los Angeles, California, 90048
Site Contact
Status
Suspended
Address
Memorial Medical Center
Modesto, California, 95355
Site Contact
Status
Suspended
Address
Kaiser Permanente Oakland-Broadway
Oakland, California, 94611
Site Contact
Status
Recruiting
Address
Kaiser Permanente-Ontario
Ontario, California, 91761
Status
Recruiting
Address
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, 92868
Status
Recruiting
Address
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California, 95661
Status
Suspended
Address
Sutter Roseville Medical Center
Roseville, California, 95661
Site Contact
Status
Recruiting
Address
Sutter Medical Center Sacramento
Sacramento, California, 95816
Status
Recruiting
Address
University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817
Status
Suspended
Address
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051
Site Contact
Status
Suspended
Address
Kaiser Permanente-South San Francisco
South San Francisco, California, 94080
Site Contact
Status
Suspended
Address
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Vacaville, California, 95687
Site Contact
Status
Suspended
Address
Sutter Solano Medical Center/Cancer Center
Vallejo, California, 94589
Site Contact
Status
Active, not recruiting
Address
The Medical Center of Aurora
Aurora, Colorado, 80012
Site Contact
Status
Active, not recruiting
Address
UCHealth University of Colorado Hospital
Aurora, Colorado, 80045
Site Contact
Status
Recruiting
Address
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907
Status
Recruiting
Address
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, 80907
Status
Active, not recruiting
Address
UCHealth Memorial Hospital Central
Colorado Springs, Colorado, 80909
Site Contact
Status
Recruiting
Address
Saint Francis Cancer Center
Colorado Springs, Colorado, 80923
Status
Recruiting
Address
Porter Adventist Hospital
Denver, Colorado, 80210
Status
Recruiting
Address
Littleton Adventist Hospital
Littleton, Colorado, 80122
Status
Recruiting
Address
Longmont United Hospital
Longmont, Colorado, 80501
Status
Recruiting
Address
Parker Adventist Hospital
Parker, Colorado, 80138
Status
Recruiting
Address
Saint Mary Corwin Medical Center
Pueblo, Colorado, 81004
Status
Recruiting
Address
Yale University
New Haven, Connecticut, 06520
Status
Recruiting
Address
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611
Status
Recruiting
Address
Sibley Memorial Hospital
Washington, District of Columbia, 20016
Status
Recruiting
Address
Boca Raton Regional Hospital
Boca Raton, Florida, 33486
Status
Recruiting
Address
University of Florida Health Science Center - Gainesville
Gainesville, Florida, 32610
Status
Recruiting
Address
Baptist MD Anderson Cancer Center
Jacksonville, Florida, 32207
Status
Recruiting
Address
Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980
Status
Recruiting
Address
AdventHealth Orlando
Orlando, Florida, 32803
Status
Recruiting
Address
Orlando Health Cancer Institute
Orlando, Florida, 32806
Status
Suspended
Address
Emory Proton Therapy Center
Atlanta, Georgia, 30308
Site Contact
Status
Suspended
Address
Emory University Hospital Midtown
Atlanta, Georgia, 30308
Site Contact
Status
Active, not recruiting
Address
Piedmont Hospital
Atlanta, Georgia, 30309
Site Contact
Status
Recruiting
Address
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322
Status
Recruiting
Address
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, 83605
Status
Recruiting
Address
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, 83687
Status
Suspended
Address
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, 83854
Site Contact
Status
Recruiting
Address
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
Status
Recruiting
Address
Illinois CancerCare-Canton
Canton, Illinois, 61520
Status
Recruiting
Address
Illinois CancerCare-Carthage
Carthage, Illinois, 62321
Status
Suspended
Address
Centralia Oncology Clinic
Centralia, Illinois, 62801
Site Contact
Status
Active, not recruiting
Address
Northwestern University
Chicago, Illinois, 60611
Site Contact
Status
Recruiting
Address
University of Illinois
Chicago, Illinois, 60612
Status
Suspended
Address
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637
Site Contact
Status
Suspended
Address
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
Site Contact
Status
Recruiting
Address
Decatur Memorial Hospital
Decatur, Illinois, 62526
Status
Recruiting
Address
Crossroads Cancer Center
Effingham, Illinois, 62401
Status
Recruiting
Address
Illinois CancerCare-Eureka
Eureka, Illinois, 61530
Status
Recruiting
Address
Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401
Status
Suspended
Address
Western Illinois Cancer Treatment Center
Galesburg, Illinois, 61401
Site Contact
Status
Recruiting
Address
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, 61443
Status
Active, not recruiting
Address
AMITA Health Adventist Medical Center
La Grange, Illinois, 60525
Site Contact
Status
Recruiting
Address
Illinois CancerCare-Macomb
Macomb, Illinois, 61455
Status
Recruiting
Address
Loyola University Medical Center
Maywood, Illinois, 60153
Status
Suspended
Address
Cancer Care Center of O'Fallon
O'Fallon, Illinois, 62269
Site Contact
Status
Recruiting
Address
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
Status
Active, not recruiting
Address
Advocate Lutheran General Hospital
Park Ridge, Illinois, 60068
Site Contact
Status
Recruiting
Address
Illinois CancerCare-Pekin
Pekin, Illinois, 61554
Status
Recruiting
Address
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Pekin, Illinois, 61554
Status
Recruiting
Address
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
Status
Recruiting
Address
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, Illinois, 61615
Status
Suspended
Address
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
Site Contact
Status
Recruiting
Address
OSF Saint Francis Medical Center
Peoria, Illinois, 61637
Status
Recruiting
Address
Illinois CancerCare-Peru
Peru, Illinois, 61354
Status
Recruiting
Address
Illinois CancerCare-Princeton
Princeton, Illinois, 61356
Status
Recruiting
Address
Memorial Medical Center
Springfield, Illinois, 62781
Status
Active, not recruiting
Address
Parkview Hospital Randallia
Fort Wayne, Indiana, 46805
Site Contact
Status
Active, not recruiting
Address
Parkview Regional Medical Center
Fort Wayne, Indiana, 46845
Site Contact
Status
Suspended
Address
Memorial Regional Cancer Center Day Road
Mishawaka, Indiana, 46545
Site Contact
Status
Suspended
Address
Memorial Hospital of South Bend
South Bend, Indiana, 46601
Site Contact
Status
Active, not recruiting
Address
McFarland Clinic - Ames
Ames, Iowa, 50010
Site Contact
Status
Suspended
Address
Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa, 50325
Site Contact
Status
Recruiting
Address
Mercy Cancer Center-West Lakes
Clive, Iowa, 50325
Status
Recruiting
Address
Greater Regional Medical Center
Creston, Iowa, 50801
Status
Recruiting
Address
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
Status
Suspended
Address
Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa, 50309
Site Contact
Status
Suspended
Address
Broadlawns Medical Center
Des Moines, Iowa, 50314
Site Contact
Status
Recruiting
Address
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
Status
Suspended
Address
Mission Cancer and Blood - Laurel
Des Moines, Iowa, 50314
Site Contact
Status
Suspended
Address
Methodist West Hospital
West Des Moines, Iowa, 50266-7700
Site Contact
Status
Suspended
Address
Mercy Medical Center-West Lakes
West Des Moines, Iowa, 50266
Site Contact
Status
Recruiting
Address
University of Kansas Cancer Center
Kansas City, Kansas, 66160
Status
Recruiting
Address
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, 66210
Status
Recruiting
Address
University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas, 66211
Status
Recruiting
Address
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, 66205
Status
Suspended
Address
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536
Site Contact
Status
Recruiting
Address
Norton Hospital Pavilion and Medical Campus
Louisville, Kentucky, 40202
Status
Recruiting
Address
Norton Brownsboro Hospital and Medical Campus
Louisville, Kentucky, 40241
Status
Recruiting
Address
West Jefferson Medical Center
Marrero, Louisiana, 70072
Status
Active, not recruiting
Address
Maine Medical Center-Bramhall Campus
Portland, Maine, 04102
Site Contact
Status
Recruiting
Address
Maine Medical Center- Scarborough Campus
Scarborough, Maine, 04074
Status
Suspended
Address
Maine Medical Partners Neurology
Scarborough, Maine, 04074
Site Contact
Status
Suspended
Address
Maine Medical Partners - South Portland
South Portland, Maine, 04106
Site Contact
Status
Recruiting
Address
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287
Status
Recruiting
Address
Walter Reed National Military Medical Center
Bethesda, Maryland, 20889-5600
Status
Recruiting
Address
Cancer Trials Support Unit
Rockville, Maryland, 20850-2062
Status
Suspended
Address
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114
Site Contact
Status
Active, not recruiting
Address
Bixby Medical Center
Adrian, Michigan, 49221
Site Contact
Status
Recruiting
Address
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109
Status
Active, not recruiting
Address
Henry Ford Hospital
Detroit, Michigan, 48202
Site Contact
Status
Recruiting
Address
Spectrum Health at Butterworth Campus
Grand Rapids, Michigan, 49503
Status
Suspended
Address
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan, 49503
Site Contact
Status
Recruiting
Address
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
Status
Active, not recruiting
Address
William Beaumont Hospital-Royal Oak
Royal Oak, Michigan, 48073
Site Contact
Status
Recruiting
Address
Munson Medical Center
Traverse City, Michigan, 49684
Status
Active, not recruiting
Address
William Beaumont Hospital - Troy
Troy, Michigan, 48085
Site Contact
Status
Recruiting
Address
University of Michigan Health - West
Wyoming, Michigan, 49519
Status
Suspended
Address
Fairview Ridges Hospital
Burnsville, Minnesota, 55337
Site Contact
Status
Recruiting
Address
Mercy Hospital
Coon Rapids, Minnesota, 55433
Status
Suspended
Address
Essentia Health Cancer Center
Duluth, Minnesota, 55805
Site Contact
Status
Recruiting
Address
Miller-Dwan Hospital
Duluth, Minnesota, 55805
Status
Recruiting
Address
Fairview Southdale Hospital
Edina, Minnesota, 55435
Status
Active, not recruiting
Address
Unity Hospital
Fridley, Minnesota, 55432
Site Contact
Status
Recruiting
Address
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
Status
Recruiting
Address
Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109
Status
Recruiting
Address
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
Status
Recruiting
Address
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
Status
Recruiting
Address
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
Status
Recruiting
Address
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
Status
Recruiting
Address
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota, 56303
Status
Recruiting
Address
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
Status
Recruiting
Address
Regions Hospital
Saint Paul, Minnesota, 55101
Status
Recruiting
Address
United Hospital
Saint Paul, Minnesota, 55102
Status
Suspended
Address
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
Site Contact
Status
Recruiting
Address
Ridgeview Medical Center
Waconia, Minnesota, 55387
Status
Suspended
Address
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125
Site Contact
Status
Recruiting
Address
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
Status
Recruiting
Address
MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia, Missouri, 65212
Status
Recruiting
Address
University of Kansas Cancer Center - North
Kansas City, Missouri, 64154
Status
Recruiting
Address
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, Missouri, 64064
Status
Recruiting
Address
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City, Missouri, 64116
Status
Recruiting
Address
Washington University School of Medicine
Saint Louis, Missouri, 63110
Status
Recruiting
Address
Mercy Hospital Saint Louis
Saint Louis, Missouri, 63141
Status
Recruiting
Address
Billings Clinic Cancer Center
Billings, Montana, 59101
Status
Suspended
Address
Saint Vincent Healthcare
Billings, Montana, 59101
Site Contact
Status
Recruiting
Address
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana, 59405
Status
Recruiting
Address
Great Falls Clinic
Great Falls, Montana, 59405
Status
Suspended
Address
CHI Health Saint Francis
Grand Island, Nebraska, 68803
Site Contact
Status
Suspended
Address
CHI Health Good Samaritan
Kearney, Nebraska, 68847
Site Contact
Status
Suspended
Address
Nebraska Hematology and Oncology
Lincoln, Nebraska, 68506
Site Contact
Status
Suspended
Address
Southeast Nebraska Cancer Center - 68th Street Place
Lincoln, Nebraska, 68516
Site Contact
Status
Recruiting
Address
Missouri Valley Cancer Consortium
Omaha, Nebraska, 68106
Status
Suspended
Address
Alegent Health Immanuel Medical Center
Omaha, Nebraska, 68122
Site Contact
Status
Recruiting
Address
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, 68124
Status
Suspended
Address
Nebraska Cancer Specialists - Omaha
Omaha, Nebraska, 68124
Site Contact
Status
Suspended
Address
Alegent Health Lakeside Hospital
Omaha, Nebraska, 68130
Site Contact
Status
Recruiting
Address
University of Nebraska Medical Center
Omaha, Nebraska, 68198
Status
Suspended
Address
Midlands Community Hospital
Papillion, Nebraska, 68046
Site Contact
Status
Suspended
Address
Regional West Medical Center Cancer Center
Scottsbluff, Nebraska, 69361
Site Contact
Status
Recruiting
Address
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada, 89106
Status
Suspended
Address
GenesisCare USA - Las Vegas
Las Vegas, Nevada, 89109
Site Contact
Status
Recruiting
Address
Radiation Oncology Centers of Nevada Southeast
Las Vegas, Nevada, 89119
Status
Suspended
Address
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, 89148
Site Contact
Status
Recruiting
Address
Renown Regional Medical Center
Reno, Nevada, 89502
Status
Recruiting
Address
Saint Mary's Regional Medical Center
Reno, Nevada, 89503
Status
Suspended
Address
Radiation Oncology Associates
Reno, Nevada, 89509
Site Contact
Status
Recruiting
Address
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756
Status
Recruiting
Address
Jersey Shore Medical Center
Neptune, New Jersey, 07753
Status
Active, not recruiting
Address
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick, New Jersey, 08903
Site Contact
Status
Active, not recruiting
Address
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903
Site Contact
Status
Active, not recruiting
Address
Overlook Hospital
Summit, New Jersey, 07902
Site Contact
Status
Recruiting
Address
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87102
Status
Active, not recruiting
Address
New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn, New York, 11215
Site Contact
Status
Active, not recruiting
Address
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032
Site Contact
Status
Recruiting
Address
University of Rochester
Rochester, New York, 14642
Status
Active, not recruiting
Address
State University of New York Upstate Medical University
Syracuse, New York, 13210
Site Contact
Status
Active, not recruiting
Address
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
Site Contact
Status
Recruiting
Address
Altru Cancer Center
Grand Forks, North Dakota, 58201
Status
Active, not recruiting
Address
Case Western Reserve University
Cleveland, Ohio, 44106
Site Contact
Status
Suspended
Address
MetroHealth Medical Center
Cleveland, Ohio, 44109
Site Contact
Status
Suspended
Address
Cleveland Clinic Foundation
Cleveland, Ohio, 44195
Site Contact
Status
Recruiting
Address
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
Status
Recruiting
Address
Riverside Methodist Hospital
Columbus, Ohio, 43214
Status
Recruiting
Address
The Mark H Zangmeister Center
Columbus, Ohio, 43219
Status
Suspended
Address
Mount Carmel Health Center West
Columbus, Ohio, 43222
Site Contact
Status
Recruiting
Address
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio, 44124
Status
Recruiting
Address
ProMedica Flower Hospital
Sylvania, Ohio, 43560
Status
Active, not recruiting
Address
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio, 44691
Site Contact
Status
Recruiting
Address
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
Status
Recruiting
Address
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, Oklahoma, 74146
Status
Suspended
Address
Clackamas Radiation Oncology Center
Clackamas, Oregon, 97015
Site Contact
Status
Active, not recruiting
Address
Legacy Mount Hood Medical Center
Gresham, Oregon, 97030
Site Contact
Status
Active, not recruiting
Address
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon, 97210
Site Contact
Status
Suspended
Address
Providence Portland Medical Center
Portland, Oregon, 97213
Site Contact
Status
Suspended
Address
Providence Saint Vincent Medical Center
Portland, Oregon, 97225
Site Contact
Status
Active, not recruiting
Address
Jefferson Abington Hospital
Abington, Pennsylvania, 19001
Site Contact
Status
Suspended
Address
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103
Site Contact
Status
Recruiting
Address
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem, Pennsylvania, 18015
Status
Active, not recruiting
Address
Geisinger Medical Center
Danville, Pennsylvania, 17822
Site Contact
Status
Recruiting
Address
Saint Luke's Hospital-Anderson Campus
Easton, Pennsylvania, 18045
Status
Recruiting
Address
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
Status
Active, not recruiting
Address
Temple University Hospital
Philadelphia, Pennsylvania, 19140
Site Contact
Status
Recruiting
Address
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212
Status
Active, not recruiting
Address
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232
Site Contact
Status
Recruiting
Address
Reading Hospital
West Reading, Pennsylvania, 19611
Status
Active, not recruiting
Address
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711
Site Contact
Status
Active, not recruiting
Address
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, 29316
Site Contact
Status
Recruiting
Address
Medical University of South Carolina
Charleston, South Carolina, 29425
Status
Suspended
Address
Greenville Health System Cancer Institute-Andrews
Greenville, South Carolina, 29601
Site Contact
Status
Active, not recruiting
Address
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina, 29605
Site Contact
Status
Active, not recruiting
Address
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605
Site Contact
Status
Active, not recruiting
Address
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, 29615
Site Contact
Status
Active, not recruiting
Address
Prisma Health Cancer Institute - Greer
Greer, South Carolina, 29650
Site Contact
Status
Active, not recruiting
Address
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, 29672
Site Contact
Status
Suspended
Address
Spartanburg Medical Center
Spartanburg, South Carolina, 29303
Site Contact
Status
Recruiting
Address
Rapid City Regional Hospital
Rapid City, South Dakota, 57701
Status
Active, not recruiting
Address
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232
Site Contact
Status
Recruiting
Address
Parkland Memorial Hospital
Dallas, Texas, 75235
Status
Recruiting
Address
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
Status
Recruiting
Address
University of Texas Medical Branch
Galveston, Texas, 77555-0565
Status
Suspended
Address
UTMB Cancer Center at Victory Lakes
League City, Texas, 77573
Site Contact
Status
Recruiting
Address
Sandra L Maxwell Cancer Center
Cedar City, Utah, 84720
Status
Recruiting
Address
Intermountain Medical Center
Murray, Utah, 84107
Status
Recruiting
Address
Utah Valley Regional Medical Center
Provo, Utah, 84604
Status
Recruiting
Address
Saint George Regional Medical Center
Saint George, Utah, 84770
Status
Suspended
Address
Utah Cancer Specialists-Salt Lake City
Salt Lake City, Utah, 84106
Site Contact
Status
Active, not recruiting
Address
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112
Site Contact
Status
Recruiting
Address
Norris Cotton Cancer Center-North
Saint Johnsbury, Vermont, 05819
Status
Recruiting
Address
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, 23298
Status
Recruiting
Address
VCU Community Memorial Health Center
South Hill, Virginia, 23970
Status
Recruiting
Address
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington, 98225
Status
Suspended
Address
Kadlec Clinic Hematology and Oncology
Kennewick, Washington, 99336
Site Contact
Status
Suspended
Address
Tri-Cities Cancer Center
Kennewick, Washington, 99336
Site Contact
Status
Active, not recruiting
Address
Skagit Regional Health Cancer Care Center
Mount Vernon, Washington, 98274
Site Contact
Status
Active, not recruiting
Address
Skagit Valley Hospital
Mount Vernon, Washington, 98274
Site Contact
Status
Active, not recruiting
Address
Virginia Mason Medical Center
Seattle, Washington, 98101
Site Contact
Status
Active, not recruiting
Address
FHCC South Lake Union
Seattle, Washington, 98109
Site Contact
Status
Active, not recruiting
Address
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109
Site Contact
Status
Suspended
Address
University of Washington Medical Center - Montlake
Seattle, Washington, 98195
Site Contact
Status
Recruiting
Address
PeaceHealth Southwest Medical Center
Vancouver, Washington, 98664
Status
Active, not recruiting
Address
West Virginia University Healthcare
Morgantown, West Virginia, 26506
Site Contact
Status
Recruiting
Address
Northwest Wisconsin Cancer Center
Ashland, Wisconsin, 54806
Status
Recruiting
Address
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
Status
Active, not recruiting
Address
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, 53215
Site Contact
Status
Recruiting
Address
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
Status
Recruiting
Address
ProHealth D N Greenwald Center
Mukwonago, Wisconsin, 53149
Status
Recruiting
Address
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066
Status
Suspended
Address
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin, 53188
Site Contact
Status
Recruiting
Address
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin, 53188
International Sites
Status
Recruiting
Address
Medical University Vienna
Vienna, , A-1090
Status
Recruiting
Address
Alegemeen Ziekenhuis Middelheim
Antwerpen, , 2020
Status
Recruiting
Address
Tom Baker Cancer Centre
Calgary, Alberta, T2N 4N2
Status
Active, not recruiting
Address
Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2
Site Contact
Status
Recruiting
Address
BCCA-Vancouver Cancer Centre
Vancouver, British Columbia, V5Z 4E6
Status
Recruiting
Address
CancerCare Manitoba
Winnipeg, Manitoba, R3E 0V9
Status
Recruiting
Address
London Regional Cancer Program
London, Ontario, N6A 4L6
Status
Suspended
Address
Ottawa Hospital and Cancer Center-General Campus
Ottawa, Ontario, K1H 8L6
Site Contact
Status
Suspended
Address
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Toronto, Ontario, M4N 3M5
Site Contact
Status
Suspended
Address
University Health Network-Princess Margaret Hospital
Toronto, Ontario, M5G 2M9
Site Contact
Status
Suspended
Address
CHUM - Hopital Notre-Dame
Montreal, Quebec, H2L 4M1
Site Contact
Status
Recruiting
Address
CHUM - Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, H2X 3E4
Status
Suspended
Address
Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1
Site Contact
Status
Recruiting
Address
Centre Leon Berard
Lyon, , 69373
Status
Recruiting
Address
Centre Antoine Lacassagne
Nice, , 06189
Status
Recruiting
Address
Gustave Roussy
Villejuif, , 94805
Status
Recruiting
Address
Academ Zienkenhuis Bij De University
Amsterdam, , 1007 MB
Status
Recruiting
Address
University Medical Center Groningen
Groningen, , 9700 GZ
Status
Recruiting
Address
Maastro Clinic-Maastricht Radiation Oncology
Maastricht, , 6229 NA
Status
Recruiting
Address
Erasmus University Medical Center
Rotterdam, , 3015 CE
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