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Transnasal Endoscopic Pituitary Surgery - the Effect of Posterior Nasal Septum Resection on Nasal Functions

Study Purpose

The aim of the project is to compare the effect of different extent of resection of the posterior part of the septum on the postoperative nasal functions.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years - 80 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - age over 18 years.
  • - patients with functional pituitary adenoma indicating endoscopic transnasal extirpation of the pituitary adenoma.

Exclusion Criteria:

  • - patients after surgery of the nasal cavity or base of the skull.
  • - patients with nasal disease and PND.
  • - patients with olfactory disorders before surgery.
- patients with nasal septal deviation

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT04782596
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

N/A
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

University Hospital Ostrava
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Jakub Lubojacký, MD
Principal Investigator Affiliation University Hospital Ostrava
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Other
Overall Status Recruiting
Countries Czechia
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Pituitary Adenoma
Additional Details

The nasal cavity is used to heat, humidify and purify the air before entering other parts of the respiratory system. Other functions of the nose include in particular olfactory, immune, reflex or sexual functions. Proper airflow through the nasal cavity is essential for all nasal functions; anatomical or flow changes can significantly affect nasal functions. Endoscopic transnasal surgical approaches are modern, mini-invasive methods, enabling solution of pathologies in the area of the cranial base, through the nasal cavity. The advantage of this technique is absence of external incisions and scars and significantly better cosmetic effect, these methods also offer very good clarity and illumination of the operating field. Main disadvantage is risk of affecting functions of the nose. To create a transnasal approach to skull base, it is necessary to perform lateralization of middle turbinates, resection of anterior wall of sphenoidal sinus and resection of posterior part of the nasal septum. These interventions are necessary for a good overview and manipulation in the operated area; however, they can lead to postoperative changes in the physiological functions of the nasal cavity, especially loss of smell, taste, altered airflow through the nasal cavity, mucociliary transport disorders, nasal obstruction, crusting or drying mucous membrane. All these adverse changes significantly affect patient's quality of life. Larger extent of septal resection allows the surgeon to have a better overview and manoeuvrability in the operated area, which allows sufficient radicality and allows the solution of possible complications. On the other hand, greater resection also means greater interference with the anatomy of the nasal cavity and possible influence on nasal functions. The aim of the project is to compare the effect of different extent of resection of the posterior part of the septum on the postoperative nasal functions. Study design:

  • - all operations will be performed by the same operations team.
  • - prior to surgery, patients will be randomly tossed into two groups according to the extent of resection of the posterior edge of the septum as part of the transsphenoidal approach during cranial base surgery.
  • - group A - Patients will be resected with a posterior 1 cm nasal septum as part of a transsphenoidal approach.
  • - group B - Patients will be resected with a 2 cm posterior nasal septum as part of a transsphenoidal approach.
  • - if the selected extent of resection is not sufficient during surgery for group A, it will be extended so that the lesion can be safely removed, and patient will be removed from study.
Operational procedure: 1. Anemization of the nasal mucosa using strips with diluted adrenaline 1: 1000. 2. Endoscopy of the nasal cavity and identification of important anatomical structures. 3. Lateralization of the middle and upper turbinates, identification of the anterior wall of the sphenoidal sinus and its natural ostium. 4. Apply suction with a marked distance of 1 and 2 cm to the septum and mark the extent of laser resection on the septal mucosa. The suction is applied paraseptally to the anterior wall of the sphenoidal sinus at the height of the natural ostium (1.5 cm above the upper edge of the choana), the caudal border of the resection is the height of the upper edge of the choana, the cranial border is the ceiling of the sphenoid. 5. Resection of the septum in the given range. 6. Resection of the anterior wall of the sphenoidal sinus, resection of the intersphenoidal septum. 7. Rest of the operation is identical in both groups of patients (tumour resection, revision of the nasal cavity, nasal tamponade).
  • - At preoperative examination and 1 month after surgery, patients will have: - endoscopy of the nasal cavity with Lund-Kennedy scoring system (evaluation of oedema, secretion, crust) - olfactory examination - test of identification and discrimination with perfumed markers.
  • - SNOT 22 questionnaire.
  • - RhinoVAS questionnaire.
  • - Nose score.
Statistical evaluation:
  • - comparison of nasal functions after cranial base surgery in patients with a range of resection of the posterior edge of the septum 1 cm and 2 cm.
- comparison of olfactory before and after surgery in both groups of patients

Arms & Interventions

Arms

Experimental: One-centimeter resection

In the study subjects enrolled into this study arm, one-centimetre resection will be used for the transnasal endoscopic pituitary surgery procedure.

Experimental: Two-centimeter resection

In the study subjects enrolled into this study arm, two-centimetre resection will be used for the transnasal endoscopic pituitary surgery procedure.

Interventions

Procedure: - Posterium nasal septum resection

Posterium nasal septum resection is required to ensure approach during transnasal endoscopic pituitary surgery in patients with pituitary adenoma.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

International Sites

University Hospital Ostrava, Ostrava, Moravian-Silesian Region, Czechia

Status

Recruiting

Address

University Hospital Ostrava

Ostrava, Moravian-Silesian Region, 70852

Site Contact

Jiří Hynčica

[email protected]

0042059737 #2587