Inclusion Criteria:
1. Able and willing to provide written informed consent and HIPAA authorization for
release of personal health information prior to registration. NOTE: HIPAA
authorization may be included in the informed consent or obtained separately.
2. Subject has histologically confirmed diagnosis of breast cancer per AJCC 8th edition
(triple negative [any BRCA status], or HER2-negative with germline or somatic BRCA
mutation).
3. 1. Subject has diagnosis of new brain metastasis by MRI, with a plan to undergo
stereotactic radiosurgery (SRS) (up to 15 untreated metastases and at least 1
metastasis with maximum dimension > 5mm). Patients are permitted to have undergone
recent craniotomy and resection of metastasis/metastases if at least 1 other intact
metastasis or gross residual tumor planned for definitive SRS is present. Patients may
have had prior SRS as long as the previously treated brain metastases are stable and
not planned for additional therapy. Re-irradiation of a lesion previously treated with
SRS is not allowed. Discrete dural lesions are allowed.
4. Subject may have other sites of extracranial metastatic disease (does not need to be
stable, as long as no signs of impending visceral crisis).
5. Subjects may have had prior systemic therapy other than combination DDR inhibitor
(PARP inhibitor) and immune checkpoint inhibitor (i.e., prior PARP inhibitor without
concurrent immune checkpoint inhibitor, or prior immune checkpoint inhibitor without
concurrent PARP inhibitor, are allowed).
6. Subject has Eastern Cooperative Oncology Group (ECOG) performance status 0-2 within 28
days prior to registration.
7. Body weight >30 kg (for durvalumab monotherapy or durvalumab combination).
8. Subject has life expectancy > 16 weeks.
9. Age ≥ 18 years at the time of consent.
10. Prior cancer treatment must be completed at least 7 days prior to treatment and the
subject must have recovered from all reversible acute toxic effects of the regimen
(other than alopecia) to Grade ≤ 1 or baseline.
11. Subject is willing and able to provide blood and tissue samples for correlative
research activities, if applicable.
12. Patients must have normal organ and bone marrow function measured within 28 days prior
to administration of study treatment as defined in the table below:
- - Platelets ≥100 x 109/L.
- - Absolute Neutrophil Count (ANC) ≥ 1.5 x 109/L.
- - Hemoglobin (Hgb) ≥ 10 g/dL with no blood transfusion in the past 28 days.
- - Calculated creatinine clearance ≥ 51 mL/min.
- - Bilirubin ≤ 1.5 × institutional upper limit of normal (ULN)
- Aspartate aminotransferase (AST) (Serum Glutamic Oxaloacetic Transaminase (SGOT))
≤ 2.5 × ULN unless liver metastases are present in which case they must be ≤ 5x
ULN.
- - Alanine aminotransferase (ALT) (Serum Glutamic Pyruvate Transaminase (SGPT))
Alanine aminotransferase (ALT) ≤ 2.5 × ULN unless liver metastases are present in
which case, they must be ≤ 5x ULN.
- - International Normalized Ratio (INR) or Prothrombin Time (PT)
- Activated Partial Thromboplastin Time (aPTT) ≤ 1.5 × ULN; Patients taking
warfarin may participate in this study; however, it is recommended that INR be
monitored carefully at least once per week for the first month, then monthly if
the INR is stable.
13. Postmenopausal or evidence of non-childbearing status for women of childbearing
potential: negative urine or serum pregnancy test within 28 days of study treatment
and confirmed prior to treatment on Day 1. Postmenopausal is defined as:
- - Amenorrheic for 1 year or more following cessation of exogenous hormonal
treatments.
- - Luteinizing hormone (LH) and Follicle stimulating hormone (FSH) levels in the
post-menopausal range for women under 50.
- - Radiation-induced oophorectomy with last menses > 1 year ago.
- - Chemotherapy-induced menopause with > 1-year interval since last menses.
- - Surgical sterilisation (bilateral oophorectomy or hysterectomy)
14.
Female patients of childbearing potential must be willing to abstain from heterosexual
activity or to use 2 highly effective methods of contraception as described in the
protocol from the time of informed consent until 3 months after treatment
discontinuation.
15. Male patients must be willing to abstain from heterosexual activity or use a condom
during treatment and for 3 months after treatment discontinuation. See the protocol
for additional information.
16. As determined by the enrolling physician or protocol designee, ability of the subject
to understand and comply with study procedures for the entire length of the study.
17. Other inclusion criteria as specified by drug manufacturer for specific
investigational drug(s), and/or required to specify disease status etc.
Exclusion Criteria:
1. Subject has evidence of diffuse symptomatic leptomeningeal carcinomatosis.
2. Subject has more than 10 untreated brain metastases or metastases with total volume >
15cc.
3. Subject has symptomatic brain metastases requiring immediate surgical resection within
1 week.
4. Subject has evidence of intracranial hemorrhage or signs of impending herniation.
5. Subject has had prior whole brain radiation therapy. Prior SRS to brain metastases is
allowed as long as previously treated lesions are stable and not planned for further
therapy.
6. Subject has had prior extracranial radiation therapy within 3 weeks of study
initiation unless palliative.
7. Subject has signs of impending visceral crisis.
8. Subject has a history of severe brain injury.
9. Receipt of the last dose of anticancer therapy (chemotherapy, immunotherapy, endocrine
therapy, targeted therapy, biologic therapy, tumor embolization, monoclonal
antibodies) ≤ 7 days prior to the first dose of study drug. If sufficient wash-out
time has not occurred (defined as 5 half-lives for the prior anti-cancer therapy), a
longer wash-out period will be required, as agreed by sponsor-investigator and the
site investigator. Concurrent use of hormonal therapy for non-cancer-related
conditions is acceptable.
10. Subject with myelodysplastic syndrome/acute myeloid leukemia or with features
suggestive of MDS/AML. 11. Resting ECG indicating uncontrolled, potentially reversible cardiac conditions, as
judged by the investigator (eg., unstable ischemia, uncontrolled symptomatic
arrhythmia, congestive heart failure, QTcF prolongation > 470 ms, electrolyte
disturbances, etc.), or patients with congenital long QT syndrome.
12. Subject has had any known Grade 3 or 4 anemia, neutropenia or thrombocytopenia due to
prior chemotherapy that persisted > 4 weeks and was related to the most recent
treatment.
13. Subject has a history of interstitial lung disease.
14. Subject has a diagnosis of primary immunodeficiency.
15. Subject must not have received colony stimulating factors (e.g., granulocyte
colony-stimulating factor, granulocyte macrophage colony stimulating factor, or
recombinant erythropoietin) within 4 weeks prior initiating study therapy.
16. Immunocompromised patients, e.g., patients who are known to be serologically positive
for human immunodeficiency virus (HIV).
17. Subject is pregnant or breastfeeding (NOTE: breast milk cannot be stored for future
use while the mother is being treated on study).
18. Subject is not eligible for sequential MRI or CT evaluations.
19. Subject with spinal cord compression unless considered to have received definitive
treatment for this and evidence of clinically stable disease for 28 days.
20. Subject unable to swallow orally administered medication and patients with
gastrointestinal disorders likely to interfere with absorption of the study
medication.
21. Concomitant use of known strong CYP3A inhibitors (eg. itraconazole, telithromycin,
clarithromycin, protease inhibitors boosted with ritonavir or cobicistat, indinavir,
saquinavir, nelfinavir, boceprevir, telaprevir) or moderate CYP3A inhibitors (eg.
ciprofloxacin, erythromycin, diltiazem, fluconazole, verapamil). The required washout
period prior to starting olaparib is 2 weeks.
22. Concomitant use of known strong (eg. phenobarbital, enzalutamide, phenytoin,
rifampicin, rifabutin, rifapentine, carbamazepine, nevirapine and St John's Wort) or
moderate CYP3A inducers (eg. bosentan, efavirenz, modafinil). The required washout
period prior to starting olaparib is 5 weeks for enzalutamide or phenobarbital and 3
weeks for other agents.
23. Previous allogenic bone marrow transplant or double umbilical cord blood
transplantation (dUCBT).
24. Participation in another clinical study with an investigational product during the
last 4 weeks. NOTE: Subjects that consented to the sub-study may enroll in the primary
therapeutic study if they meet all eligibility criteria outlined in Section 3.1.
25. Concurrent enrollment in another clinical study, unless it is an observational
(non-interventional) clinical study or during the follow-up period of an
interventional study. NOTE: Subjects that consented to the sub-study may enroll in the
primary therapeutic study if they meet all eligibility criteria outlined in Section
3.1.
26. Any unresolved toxicity NCI CTCAE Grade ≥ 2 from previous anticancer therapy with the
exception of alopecia, vitiligo, and the laboratory values defined in the inclusion
criteria.
- - Patients with Grade ≥ 2 neuropathy will be evaluated on a case-by-case basis
after consultation with the sponsor-investigator.
- - Patients with irreversible toxicity not reasonably expected to be exacerbated by
treatment with durvalumab may be included only after consultation with the
sponsor-investigator.
27. Radiotherapy treatment to more than 30% of the bone marrow or with a wide field of
radiation within 4 weeks of the first dose of study drug.
28. Major surgical procedure (as defined by the Investigator) within 28 days prior to the
first dose of investigational product (IP). NOTE: Resection of brain metastasis and
local surgery of isolated lesions for palliative intent is acceptable.
29. Active or prior documented autoimmune or inflammatory disorders (including
inflammatory bowel disease [e.g., colitis or Crohn's disease], diverticulitis [with
the exception of diverticulosis], systemic lupus erythematosus, Sarcoidosis syndrome,
or Wegener syndrome [granulomatosis with polyangiitis, Graves' disease, rheumatoid
arthritis, hypophysitis, uveitis, etc]). The following are exceptions to this
criterion:
- - Patients with vitiligo or alopecia.
- - Patients with hypothyroidism (e.g., following Hashimoto syndrome) stable on
hormone replacement.
- - Any chronic skin condition that does not require systemic therapy.
- - Patients without active disease in the last 5 years may be included but only
after consultation with the sponsor-investigator.
- - Patients with celiac disease controlled by diet alone.
30. Uncontrolled intercurrent illness, including but not limited to, ongoing or active
infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable
angina pectoris, cardiac arrhythmia, interstitial lung disease, serious chronic
gastrointestinal conditions associated with diarrhea, myocardial infarction,
uncontrolled major seizure disorder, unstable spinal cord compression, superior vena
cava syndrome or psychiatric illness/social situations that would limit compliance
with study requirement, substantially increase risk of incurring AEs or compromise the
ability of the patient to give written informed consent.
31. History of another primary malignancy except for:
- - Malignancy treated with curative intent and with no known active disease ≥5 years
before the first dose of IP and of low potential risk for recurrence.
- - Adequately treated non-melanoma skin cancer or lentigo maligna without evidence
of disease.
- - Adequately treated carcinoma in situ without evidence of disease.
32. Current or prior use of immunosuppressive medication within 14 days before the first
dose of durvalumab. The following are exceptions to this criterion:
- - Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra
articular injection).
- - Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of
prednisone or its equivalent.
- - Steroids as premedication for hypersensitivity reactions (e.g., CT scan
premedication).
- - Steroids used to treat edema from SRS as per protocol.
33. Receipt of live attenuated vaccine within 30 days prior to the first dose of IP. Note:
Patients, if enrolled, should not receive live vaccine whilst receiving IP and up to
30 days after the last dose of IP.
34. Known allergy or hypersensitivity to any of the study drugs or any of the study drug
excipients.
35. Prior randomization or treatment in a previous durvalumab clinical study regardless of
treatment arm assignment.
36. Patients who have received prior anti-PD-1, anti PD-L1 or anti CTLA-4:
- - Must not have experienced a toxicity that led to permanent discontinuation of
prior immunotherapy.
- - All AEs while receiving prior immunotherapy must have completely resolved or
resolved to baseline prior to screening for this study.
- - Must not have experienced a ≥ Grade 3 immune related AE or an immune related
neurologic or ocular AE of any grade while receiving prior immunotherapy.
NOTE:
Patients with endocrine AE of ≤ Grade 2 are permitted to enroll if they are
stably maintained on appropriate replacement therapy and are asymptomatic.
- - Must not have required the use of additional immunosuppression other than
corticosteroids for the management of an AE, not have experienced recurrence of
an AE if re-challenged, and not currently require maintenance doses of > 10 mg
prednisone or equivalent per day.
37. Clinically significant acute infection requiring systemic antibacterial, antifungal,
or antiviral therapy including:
- - tuberculosis (clinical evaluation that includes clinical history, physical
examination, and radiographic findings, and TB testing in line with local
practice),
- hepatitis B (known positive HBV surface antigen (HBsAg) result),
- hepatitis C, or.
- - human immunodeficiency virus (positive HIV 1/2 antibodies).
NOTE: Patients with a past or resolved HBV infection (defined as the presence of hepatitis
B core antibody [anti-HBc] and absence of HBsAg) are eligible. Patients positive for
hepatitis C (HCV) antibody are eligible only if polymerase chain reaction is negative for
HCV RNA. Subjects with HIV/AIDS with adequate antiviral therapy to control viral load would
be allowed if they are stable and have been on treatment for ≥ 4 weeks prior to first dose
of study drug(s). Subjects with viral hepatitis with controlled viral load would be allowed
while on suppressive antiviral therapy. Testing not required.
Eligibility Criteria for surgical sub-study. Inclusion Criteria. Subjects planned for surgical resection of their brain metastasis must meet the following
criteria:
1. Subject is planned for surgical resection of their brain metastasis. NOTE: subjects
with acutely symptomatic brain metastasis requiring surgical resection within 1 week
are not eligible for the sub-study.
2. Subject meets inclusion criteria #1, 2, 4, 6, 8-16 above.1 Female patients of
child-bearing potential and male patients must be willing to abstain from heterosexual
intercourse or use contraception as described in protocol.
Exclusion Criteria. Subjects meeting any of the criteria below may not participate in the surgical sub-study:
1. Subject has acutely symptomatic brain metastasis requiring surgical resection within 1
week.
2. Subject meets criteria #1, 2, 4, 7-17, 20-25, 27-28, 30, 33-34 above from section.
